The spirit of Santa Fe runs deep: The high-desert New Mexico town at the edge of the Sangre de Cristo hills is a place for artists and adventurers, spa lovers and shoppers—a place where never-ending blue skies meet majestic deserts. Furthermore, luminaries such as Georgia O’Keeffe found boundless inspiration here, and the enduring culture of tribes like the Apache and Navajo remains a vital part of everyday life. Consequently, with so much to engage every type of traveler, it’s no surprise thatGoTravelDailyreaders rank it among their top destinations in the American Southwest.