Top Cities in Central and South America: Readers’ Picks for 2025

Summary

Cuzco, Peru
Antigua Guatemala, Guatemala
Rio de Janeiro
São Paulo, Brazil
Lima
Cartagena, Colombia
Buenos Aires
Quito, Ecuador
Bogotá, Colombia
Montevideo, Uruguay

From the vibrant nightlife of Rio de Janeiro’s Copacabana to the art galleries and historic architecture of Cuzco, the best cities in Central and South America captivate travelers. According to GoTravelDaily readers, the appeal of these regions remains strong. In 2022, the most-loved cities featured long-time favorites such as Lima and Buenos Aires alongside intriguing newcomers like Montevideo, Uruguay’s coastal capital.

Every year, GoTravelDaily conducts its World’s Best Awards survey, soliciting readers’ insights on travel experiences globally. Participants share opinions on top cities across various criteria including sights, culture, cuisine, friendliness, shopping, and value.

Notably, the charming city of Cuzco, Peru, clinched the top spot. Cities in Brazil, Colombia, and beyond also continued to impress GoTravelDaily readers. São Paulo, once ranked No. 10 in 2021, rose to No. 4 this year due to its architectural marvels and new luxury hotels. Rio de Janeiro, now at No. 3, won acclaim for its lively music scene, delicious food, and trendy neighborhoods like Leblon and Ipanema.

Colombia’s top cities include Bogotá at No. 9 and UNESCO-listed Cartagena at No. 6. One reader highlighted staying in the Old Town of Cartagena at the Movich Hotel, known for its intimate setting and proximity to the city’s historic churches. Meanwhile, in Montevideo, travelers enjoy small eateries, known as boliches, famed for serving the finest beef asado in South America.

Explore those cities that readers consider the finest in Central and South America below.

1. Cuzco, Peru

This city is a must for anyone interested in South American history. Its unique location and profound Indigenous roots make it a cultural epicenter. Once the heart of the Incan Tawantinsuyu empire, Cuzco boasts a stunning landscape surrounded by the Vilcabamba Mountains. The city’s high elevation of 12,000 feet may take your breath away, along with its rich history and culinary scene, which includes numerous organic options and chocolate-making classes.

Score: 88.79